Hydrogen-bonded DeUG x DAN heterocomplex: structure and stability and a scalable synthesis of DeUG with reactive functionality.

نویسندگان

  • Darrell W Kuykendall
  • Cyrus A Anderson
  • Steven C Zimmerman
چکیده

A convenient, scalable synthesis of the supramolecular building block 7-deazaguanine-based urea (DeUG) is reported. Incorporation of reactive moieties (DeUG azide 10 and alkyne 11 for copper-catalyzed azide-alkyne cycloadditions, "click chemistry") and a demonstration of transesterification (DeUG glycol, 12) highlights the versatility. X-ray structures of DeUG and a DeUG x DAN heterocomplex were obtained. K(assoc) for the 1.2 heterocomplex was estimated to be 2 x 10(8) M(-1) in chloroform.

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عنوان ژورنال:
  • Organic letters

دوره 11 1  شماره 

صفحات  -

تاریخ انتشار 2009